Hydrogen Water Filter: The Future of Hydration?

Hydrogen Water Filter: The Future of Hydration?

Introduction

In recent years, hydrogen water filters have emerged as a promising innovation in the realm of water purification and health enhancement. These advanced systems combine traditional water filtration with the infusion of molecular hydrogen (H2), offering a unique approach to hydration that has captured the attention of health enthusiasts and researchers alike. As we delve into the world of hydrogen water filters, it's essential to understand their potential benefits and the science behind this technology.

Hydrogen water filters are designed to not only remove common contaminants from water but also to enrich it with dissolved hydrogen gas. This process is based on the principle that molecular hydrogen may act as a selective antioxidant in the body, potentially offering a range of health benefits (Ohta, 2011). Unlike conventional water filters, these systems aim to create water that goes beyond mere purification, potentially contributing to overall well-being.

The growing interest in hydrogen water filters stems from a body of research suggesting that hydrogen-rich water may have anti-inflammatory and antioxidant effects. Studies have explored its potential impact on various aspects of health, including cognitive function, athletic performance, and metabolic health (Ohsawa et al., 2007; Aoki et al., 2012). However, it's crucial to approach these claims with a critical eye, as the field is still evolving, and more research is needed to fully understand the long-term effects and optimal use of hydrogen-enriched water.

Here is the main body of the article on hydrogen water filters:

Understanding Hydrogen Water Filtration Systems

What are Hydrogen Water Filtration Systems?

Hydrogen water filtration systems are innovative devices that combine traditional water purification with the infusion of molecular hydrogen (H2) gas into drinking water. These systems go beyond standard filtration by not only removing contaminants but also enriching the water with dissolved hydrogen, which may offer potential health benefits.

At their core, hydrogen water filters consist of two main components: a filtration unit and a hydrogen infusion mechanism. The filtration unit typically employs multi-stage filtration to remove common water contaminants such as chlorine, heavy metals, and sediment. This may include activated carbon filters, sediment filters, and in some cases, reverse osmosis membranes. The hydrogen infusion component then introduces molecular hydrogen into the purified water through various methods, most commonly electrolysis or magnesium-based reactions.

What sets hydrogen water filters apart from conventional water purifiers is their ability to produce water with a high concentration of dissolved hydrogen gas. While regular filtered water may have a hydrogen concentration of less than 0.1 parts per million (ppm), hydrogen-rich water produced by these systems can contain up to 1.6 ppm or more of dissolved hydrogen (Ohta, 2011). This significant increase in hydrogen content is what proponents believe may confer additional health benefits beyond basic hydration and purification.

The Science Behind Hydrogen-Rich Water

The concept of hydrogen-rich water is rooted in the unique properties of molecular hydrogen. As the smallest and lightest molecule in the universe, hydrogen possesses several characteristics that make it potentially beneficial for human health:

  1. Selective Antioxidant Properties: Unlike other antioxidants, molecular hydrogen is selective in its reactivity. It primarily targets highly reactive and cytotoxic free radicals, such as hydroxyl radicals, while not interfering with beneficial reactive oxygen species involved in cell signaling (Ohsawa et al., 2007).

  2. Cell Membrane Permeability: Due to its small size, hydrogen can easily diffuse through cell membranes and enter subcellular compartments, including mitochondria and nuclei. This allows it to potentially exert effects at the cellular level where other antioxidants may not reach (Ohta, 2015).

  3. No Known Toxic Effects: Even at high concentrations, molecular hydrogen has not shown any toxic effects in the body, making it a potentially safe therapeutic option (Ostojic, 2015).

The proposed mechanisms of action for hydrogen-rich water include:

  • Reduction of oxidative stress by neutralizing harmful free radicals
  • Modulation of cell signaling pathways involved in inflammation and metabolism
  • Enhancement of mitochondrial function and energy production
  • Potential epigenetic effects through regulation of gene expression

While these mechanisms are supported by preclinical studies, it's important to note that more research is needed to fully understand how hydrogen-rich water may impact human health in various conditions.

Types of Hydrogen Water Systems

There are several types of hydrogen water systems available on the market, each with its own advantages and considerations:

  1. Countertop/Benchtop Filters: These are standalone units that sit on a kitchen counter and connect to the faucet via a diverter valve. They offer convenience and are suitable for renters or those who don't want to modify their plumbing. Examples include the UltraStream and Echo H2 Machine.

  2. Undersink Systems: Installed beneath the sink, these systems provide filtered and hydrogen-rich water through a dedicated faucet. They offer a more permanent and integrated solution but may require professional installation. The AlkaViva Vesta H2 is an example of this type.

  3. Portable Bottles: These are battery-operated devices that allow users to create hydrogen-rich water on-the-go. While convenient for travel, they typically produce lower hydrogen concentrations compared to larger systems.

  4. Hydrogen Tablets: A non-electronic option, these tablets dissolve in water to release hydrogen gas. They are portable and easy to use but may not provide as consistent or high levels of hydrogen as machine-based systems.

When choosing a hydrogen water system, consumers should consider factors such as:

  • Filtration capabilities and contaminants removed
  • Hydrogen concentration produced (measured in parts per million)
  • Flow rate and daily capacity
  • Ease of installation and maintenance
  • Filter lifespan and replacement costs
  • Certifications and independent testing results

It's crucial to evaluate these factors in the context of individual needs and water quality to select the most appropriate system.

Potential Health Benefits of Hydrogen-Rich Water

Reducing Oxidative Stress and Inflammation

One of the primary proposed benefits of hydrogen-rich water is its potential to reduce oxidative stress and inflammation in the body. Oxidative stress occurs when there is an imbalance between free radicals and antioxidants, leading to cellular damage and contributing to various chronic diseases.

Molecular hydrogen acts as a selective antioxidant, primarily targeting highly reactive and harmful free radicals such as hydroxyl radicals. A study by Ohsawa et al. (2007) demonstrated that hydrogen could selectively reduce cytotoxic oxygen radicals without affecting physiological reactive oxygen species involved in cell signaling. This selective action may help maintain cellular homeostasis while mitigating oxidative damage.

In terms of inflammation, several studies have suggested that hydrogen-rich water may have anti-inflammatory effects. For example, a randomized, double-blind, placebo-controlled study by Aoki et al. (2012) found that drinking hydrogen-rich water for 4 weeks reduced biomarkers of inflammation in patients with rheumatoid arthritis. However, it's important to note that while these results are promising, more large-scale human studies are needed to confirm these effects across various populations and conditions.

Cognitive Function and Brain Health

The potential neuroprotective effects of hydrogen-rich water have garnered significant interest in the scientific community. The ability of molecular hydrogen to cross the blood-brain barrier makes it a promising candidate for supporting brain health and cognitive function.

A study by Ohta et al. (2011) in animal models suggested that hydrogen-rich water could prevent cognitive decline associated with oxidative stress and neuroinflammation. In human studies, Nishimaki et al. (2018) found that elderly individuals with mild cognitive impairment who consumed hydrogen-rich water for 1 year showed improvements in attention and memory compared to a placebo group.

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While these findings are encouraging, it's crucial to approach them with caution. The long-term effects of hydrogen-rich water on cognitive function in humans, particularly in the context of neurodegenerative diseases, require further investigation through larger, more comprehensive clinical trials.

Athletic Performance and Recovery

The potential impact of hydrogen-rich water on athletic performance and recovery has been a subject of growing interest. The proposed benefits are primarily attributed to hydrogen's ability to reduce exercise-induced oxidative stress and inflammation.

A study by Aoki et al. (2012) found that soccer players who consumed hydrogen-rich water before exercise showed reduced blood lactate levels and improved exercise-induced decline of muscle function. Another study by Kawamura et al. (2020) suggested that hydrogen-rich water consumption could enhance endurance performance and reduce fatigue in trained athletes.

However, it's important to note that while these results are promising, the effects of hydrogen-rich water on athletic performance may vary depending on factors such as the type of exercise, intensity, and individual physiology. More research is needed to establish optimal protocols for using hydrogen-rich water in sports and exercise contexts.

Metabolic Health and Type 2 Diabetes

Emerging research suggests that hydrogen-rich water may have potential benefits for metabolic health, particularly in the context of type 2 diabetes. The proposed mechanisms include improved insulin sensitivity and regulation of blood glucose levels.

A randomized, double-blind, placebo-controlled study by Kajiyama et al. (2008) found that patients with type 2 diabetes and impaired glucose tolerance who consumed hydrogen-rich water for 8 weeks showed improvements in markers of oxidative stress and insulin resistance. Another study by Song et al. (2013) demonstrated that hydrogen-rich water consumption improved lipid and glucose metabolism in patients with metabolic syndrome.

While these findings are encouraging, it's crucial to emphasize that hydrogen-rich water should not be considered a replacement for established diabetes treatments. More extensive clinical trials are needed to fully understand the long-term effects and optimal use of hydrogen-rich water in managing metabolic disorders.

Skin Health and Anti-Aging Effects

The potential benefits of hydrogen-rich water for skin health have also been explored, primarily due to its antioxidant properties and ability to neutralize free radicals that contribute to skin aging.

A study by Kato et al. (2012) found that bathing in hydrogen-rich water improved skin wrinkles and moisture content in human subjects. Another study by Ishibashi et al. (2015) suggested that drinking hydrogen-rich water could have protective effects against UV-induced skin damage.

While these results are intriguing, it's important to approach claims about anti-aging effects with caution. The long-term impact of hydrogen-rich water on skin health and aging processes requires further investigation through more comprehensive and extended clinical trials.

Key Features of Hydrogen Water Filtration Systems

Filtration Capabilities

Hydrogen water filtration systems typically incorporate multi-stage filtration processes to ensure comprehensive water purification. Common contaminants removed by these systems include:

  • Chlorine and chloramines
  • Heavy metals (e.g., lead, mercury, copper)
  • Sediment and particulate matter
  • Organic compounds and pesticides
  • Fluoride (in some models with specialized filters)

The filtration technologies used may include:

  1. Activated Carbon: Highly effective at removing chlorine, organic compounds, and improving taste and odor.
  2. Sediment Filters: Remove larger particles and debris.
  3. KDF (Kinetic Degradation Fluxion) Media: Helps remove heavy metals and extends the life of carbon filters.
  4. Reverse Osmosis (in some high-end models): Provides thorough filtration, removing up to 99% of contaminants.

It's important to note that the specific filtration capabilities can vary significantly between different models and brands. Consumers should carefully review the filtration specifications and certifications of any system they are considering.

Hydrogen Infusion Methods

There are two primary methods used in hydrogen water filtration systems to infuse water with molecular hydrogen:

  1. Electrolysis: This method uses an electric current to split water molecules into hydrogen and oxygen. The hydrogen gas is then dissolved into the water. Electrolysis-based systems can typically produce higher concentrations of hydrogen but require a power source.

  2. Magnesium-based Infusion: This method uses a reaction between water and magnesium to produce hydrogen gas. The reaction is typically: Mg + 2H2O → Mg(OH)2 + H2. This method doesn't require electricity but may produce lower hydrogen concentrations compared to electrolysis.

Factors affecting hydrogen concentration include: - Water temperature (colder water can hold more dissolved hydrogen) - Water pressure - Flow rate - Quality of the infusion technology

Most high-quality systems aim to produce hydrogen concentrations between 0.8 to 1.6 parts per million (ppm), although some may claim higher levels.

Alkalizing Properties

Many hydrogen water filtration systems also have the capability to increase the pH of the water, making it more alkaline. This is often achieved through the use of alkaline minerals or as a byproduct of the hydrogen infusion process.

Typical pH ranges for hydrogen-rich alkaline water are between 8.5 to 9.5, compared to neutral water at pH 7. However, it's important to note that the relationship between water alkalinity and health benefits is a subject of ongoing debate in the scientific community.

The alkalizing effect is often attributed to: - The presence of alkaline minerals like calcium and magnesium - The reduction of dissolved CO2 during the hydrogen infusion process - The production of hydroxide ions during electrolysis

While some proponents claim various health benefits from alkaline water, more research is needed to substantiate many of these claims.

Oxidation-Reduction Potential (ORP)

Oxidation-Reduction Potential (ORP) is a measure of the water's ability to act as an antioxidant or oxidant. A negative ORP indicates antioxidant potential, while a positive ORP suggests oxidizing potential.

Hydrogen-rich water typically has a negative ORP, often ranging from -200 to -600 mV, depending on the system and hydrogen concentration. This negative ORP is believed to contribute to the water's antioxidant properties.

It's important to note that while ORP can be an indicator of antioxidant potential, it doesn't directly correlate with health benefits. The actual impact on health depends on various factors, including the bioavailability and stability of the dissolved hydrogen.

Choosing the Right Hydrogen Water System

Evaluating Filtration Effectiveness

When selecting a hydrogen water system, it's crucial to assess its filtration capabilities thoroughly. Look for systems that have been certified by reputable organizations such as NSF International or the Water Quality Association (WQA). These certifications ensure that the system has been independently tested and meets specific standards for contaminant reduction.

Key factors to consider include:

  1. Filter Micron Rating: This indicates the size of particles the filter can remove. Lower micron ratings (e.g., 0.5 micron) generally indicate more effective filtration.

  2. Contaminants Removed: Check the system's specifications for a list of specific contaminants it can remove and the percentage of reduction for each.

  3. Filter Lifespan: Consider how often filters need to be replaced and the cost of replacement filters.

  4. Flow Rate: Ensure the system can produce enough filtered water for your daily needs without significant wait times.

Assessing Hydrogen Production

The effectiveness of a hydrogen water system largely depends on its ability to consistently produce water with a sufficient concentration of dissolved hydrogen. When evaluating hydrogen production, consider the following:

  1. Hydrogen Concentration: Look for systems that can produce water with at least 0.8 to 1.6 parts per million (ppm) of dissolved hydrogen. Some high-end systems may claim higher concentrations.

  2. Measurement Methods: Understand how the hydrogen concentration is measured. Dissolved hydrogen meters or titration methods are generally more reliable than ORP measurements alone.

  3. Consistency: Consider whether the system can maintain consistent hydrogen levels over time and with varying water conditions.

  4. Stability: Assess how long the water retains its hydrogen content after production. Some systems may include features to help maintain hydrogen levels during storage.

Installation and Maintenance Requirements

The ease of installation and ongoing maintenance needs are important factors to consider when choosing a hydrogen water system. Different types of systems have varying requirements:

  1. Countertop Systems: Generally the easiest to install, often requiring only a simple connection to the faucet via a diverter valve. Maintenance typically involves regular filter changes and occasional cleaning.

  2. Undersink Systems: May require professional installation, especially if plumbing modifications are needed. These systems often have more complex maintenance requirements but can offer higher capacity and more seamless integration with existing fixtures.

  3. Portable Systems: Require minimal installation but may need more frequent maintenance and battery replacements.

Consider your technical skills, available space, and willingness to perform regular maintenance when choosing a system. Also, factor in the availability and cost of replacement parts and filters.

Cost Considerations

When evaluating the cost of a hydrogen water system, it's important to consider both the initial investment and long-term expenses:

  1. Initial Cost: Prices can range from a few hundred dollars for basic countertop models to several thousand for high-end undersink systems.

  2. Replacement Filters: Factor in the cost and frequency of filter replacements. Some systems may require multiple filter changes per year.

  3. Energy Costs: For systems that use electrolysis, consider the potential impact on electricity bills, especially for continuous use.

  4. Maintenance Costs: Include potential costs for professional servicing or replacement of non-filter components.

  5. Water Usage: Some systems, particularly those with reverse osmosis, may increase water usage and potentially affect water bills.

Compare these costs with alternatives like bottled hydrogen water to determine the most cost-effective solution for your needs. Keep in mind that while initial costs may be higher for some systems, they could offer savings in the long run compared to regularly purchasing bottled water.

Popular Hydrogen Water System Brands and Models

UltraStream

The UltraStream is a popular countertop hydrogen water filter system known for its comprehensive filtration and hydrogen infusion capabilities. Key features include:

  • Multi-stage filtration including KDF, activated carbon, and ceramic media
  • Magnesium-based hydrogen infusion method
  • Alkalizing capabilities
  • Claimed hydrogen output of up to 1.1 ppm
  • Filter life of approximately 3,785 liters (1,000 gallons)

User reviews generally praise the UltraStream for its ease of use and noticeable improvement in water taste. However, some users note that the system can be bulky for smaller kitchens.

Echo H2 Machine

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The Echo H2 Machine is an electrolysis-based hydrogen water generator that focuses on high hydrogen output. Notable features include:

  • Electrolysis technology for hydrogen production
  • Claimed hydrogen output of up to 1.6 ppm
  • Multiple water settings (purified, hydrogen-rich, strong hydrogen)
  • Compact design suitable for countertop use

Users appreciate the Echo H2 Machine for its high hydrogen output and versatility. However, some find the electrolysis process slower compared to flow-through systems.

AlkaViva Vesta H2

The AlkaViva Vesta H2 is an undersink hydrogen water system that combines advanced filtration with hydrogen infusion. Key features include:

  • Dual internal filters for comprehensive contaminant removal
  • Electrolysis technology for

Conclusion

Hydrogen water filtration systems represent an intriguing advancement in water treatment technology, offering potential benefits that extend beyond traditional purification. As we've explored throughout this article, these systems combine effective contaminant removal with the infusion of molecular hydrogen, aiming to provide water that may support overall health and well-being.

The potential advantages of hydrogen-rich water, including its antioxidant properties and possible effects on inflammation, cognitive function, and athletic performance, have garnered significant interest in both scientific and consumer circles. However, it's crucial to approach these benefits with a balanced perspective. While some studies have shown promising results, the field of hydrogen water research is still evolving, and more comprehensive, long-term studies are needed to fully understand its effects on human health.

When considering a hydrogen water filter for your home, it's important to weigh several factors. The filtration effectiveness, hydrogen production capabilities, ease of installation and maintenance, and overall cost should all play a role in your decision-making process. High-quality systems like the UltraStream, Echo H2 Machine, and AlkaViva Vesta H2 offer various features and benefits, but the best choice will depend on your specific needs, budget, and water quality concerns.

As with any health-related product, it's advisable to consult with healthcare professionals before incorporating hydrogen-rich water into your daily routine, especially if you have existing health conditions or are taking medications. Additionally, while hydrogen water filters may offer potential benefits, they should be viewed as a complement to, rather than a replacement for, a balanced diet, regular exercise, and other healthy lifestyle practices.

Looking ahead, the field of hydrogen water technology is likely to continue evolving, with ongoing research potentially uncovering new applications and refining our understanding of its effects. As consumers, staying informed about the latest developments and maintaining a critical, evidence-based approach will be key to making the most of this innovative water treatment option.

Ultimately, hydrogen water filters represent an exciting frontier in the quest for optimized hydration and potential health support. While they may not be a panacea, for those interested in exploring cutting-edge water treatment technologies, these systems offer a unique approach to enhancing the quality of the water we consume daily.

Key Highlights and Actionable Tips

  • Hydrogen water filters combine traditional water purification with infusion of molecular hydrogen (H2)
  • Potential benefits include reducing oxidative stress, supporting cognitive function, and aiding athletic recovery
  • Look for systems producing 0.8-1.6 ppm of dissolved hydrogen for optimal effects
  • Consider filtration capabilities, ease of installation/maintenance, and long-term costs when choosing a system
  • Popular brands include UltraStream, Echo H2 Machine, and AlkaViva Vesta H2
  • Consult healthcare professionals before incorporating hydrogen-rich water into your routine
  • View hydrogen water as a complement to, not replacement for, a healthy lifestyle

How does the hydrogen concentration in water affect its potential benefits?

The concentration of dissolved hydrogen in water is a key factor in its potential therapeutic effects. Generally, higher concentrations are associated with greater benefits. Most high-quality systems aim to produce hydrogen concentrations between 0.8 to 1.6 parts per million (ppm). Some studies have shown that concentrations in this range may be effective for reducing oxidative stress and inflammation (Ohta, 2011). However, the optimal concentration may vary depending on the specific health condition or desired effect. It's important to note that very high concentrations above 2 ppm are difficult to achieve and maintain in water at normal temperature and pressure.

Can hydrogen water filters remove fluoride from tap water?

While many hydrogen water filters are effective at removing a wide range of contaminants, fluoride removal capabilities can vary significantly between models. Some high-end systems may include specialised filters designed to reduce fluoride levels, but this is not a standard feature in all hydrogen water filters. If fluoride removal is a priority, look for systems that specifically mention this capability in their specifications. Alternatively, consider using a pre-filter or separate fluoride removal system in conjunction with your hydrogen water filter. Always check the detailed filtration specifications of any system you're considering to ensure it meets your specific water quality needs.

How long does hydrogen-rich water retain its properties after filtration?

The stability of hydrogen-rich water is an important consideration, as the dissolved hydrogen can gradually escape over time. Generally, hydrogen-rich water begins to lose its hydrogen content as soon as it's exposed to air. The rate of loss can vary depending on factors such as temperature, surface area exposed to air, and initial hydrogen concentration. Some studies suggest that hydrogen-rich water can retain a significant portion of its hydrogen content for several hours when stored properly in a sealed container (Ishibashi et al., 2015). To maximise the potential benefits, it's generally recommended to consume hydrogen-rich water as soon as possible after production or store it in a tightly sealed, full container with minimal air space.

Are there any potential side effects or risks associated with drinking hydrogen-rich water?

Hydrogen-rich water is generally considered safe for consumption, with no known toxic effects even at high concentrations (Ostojic, 2015). However, as with any significant change to your diet or health routine, some individuals may experience mild digestive discomfort when first introducing hydrogen-rich water. It's also important to note that while hydrogen water itself is not known to have direct negative effects, relying solely on it as a health solution while neglecting other aspects of a healthy lifestyle could be counterproductive. Additionally, those with specific health conditions or taking medications should consult with a healthcare professional before making hydrogen-rich water a regular part of their diet, as it may interact with certain treatments or conditions in ways that are not yet fully understood.

How does the alkalising effect of hydrogen water filters compare to dedicated alkaline water systems?

While many hydrogen water filters also have alkalising capabilities, their primary focus is on infusing water with molecular hydrogen. The alkalising effect in hydrogen water systems is often a byproduct of the hydrogen infusion process or the use of alkaline minerals in the filtration media. Dedicated alkaline water systems, on the other hand, are specifically designed to increase water pH, often through electrolysis or mineral addition. As a result, dedicated alkaline systems may produce water with higher pH levels (typically 8.8-9.5) compared to hydrogen water filters (usually 8.5-9.0). However, it's important to note that the relationship between water alkalinity and health benefits is still a subject of ongoing research and debate in the scientific community. The potential benefits of hydrogen-rich water are more closely linked to its hydrogen content rather than its pH level.

References (Click to Expand)

Aoki, K., Nakao, A., Adachi, T., Matsui, Y., & Miyakawa, S. (2012). Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Medical Gas Research, 2(1), 12. https://doi.org/10.1186/2045-9912-2-12

Ishibashi, T., Sato, B., Rikitake, M., Seo, T., Kurokawa, R., Hara, Y., ... & Nagao, T. (2015). Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Medical Gas Research, 5(1), 12. https://doi.org/10.1186/s13618-015-0033-3

Kajiyama, S., Hasegawa, G., Asano, M., Hosoda, H., Fukui, M., Nakamura, N., ... & Nakano, K. (2008). Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research, 28(3), 137-143. https://doi.org/10.1016/j.nutres.2008.01.008

Kato, S., Saitoh, Y., Iwai, K., & Miwa, N. (2012). Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. Journal of Photochemistry and Photobiology B: Biology, 106, 24-33. https://doi.org/10.1016/j.jphotobiol.2011.09.006

Kawamura, T., Gando, Y., Takahashi, M., Hara, R., Suzuki, K., & Muraoka, I. (2020). Effects of hydrogen bathing on exercise-induced oxidative stress and delayed-onset muscle soreness. Japanese Journal of Physical Fitness and Sports Medicine, 69(1), 39-52. https://doi.org/10.7600/jspfsm.69.39

Nishimaki, K., Asada, T., Ohsawa, I., Nakajima, E., Ikejima, C., Yokota, T., ... & Ohta, S. (2018). Effects of molecular hydrogen assessed by an animal model and a randomized clinical study on mild cognitive impairment. Current Alzheimer Research, 15(5), 482-492. https://doi.org/10.2174/1567205014666171106145017

Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., ... & Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 13(6), 688-694. https://doi.org/10.1038/nm1577

Ohta, S. (2011). Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications. Current Pharmaceutical Design, 17(22), 2241-2252. https://doi.org/10.2174/138161211797052664

Ohta, S. (2015). Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. Pharmacology & Therapeutics, 144(1), 1-11. https://doi.org/10.1016/j.pharmthera.2014.04.006

Ostojic, S. M. (2015). Molecular hydrogen: An inert gas turns clinically effective. Annals of Medicine, 47(4), 301-304. https://doi.org/10.3109/07853890.2015.1034765

Song, G., Li, M., Sang, H., Zhang, L., Li, X., Yao, S., ... & Qin, S. (2013). Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. Journal of Lipid Research, 54(7), 1884-1893. https://doi.org/10.1194/jlr.M036640


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