Hydrogen Water Woolworths: Trend or Health Boost?

Hydrogen Water Woolworths: Trend or Health Boost?

Introduction

In recent years, hydrogen water has emerged as a popular beverage trend, with claims of potential health benefits ranging from improved hydration to reduced oxidative stress. Woolworths, one of Australia's leading supermarket chains, has embraced this trend by offering a range of hydrogen water products under the Boundless brand. This article explores the concept of hydrogen water, its availability at Woolworths, and the scientific evidence behind its purported benefits.

Hydrogen water, as the name suggests, is water infused with molecular hydrogen (H2). This process typically involves dissolving hydrogen gas into water through various methods, such as electrolysis or nanobubble infusion technology (Ohta, 2011). The resulting product is claimed to have antioxidant properties and potential health benefits due to the presence of dissolved hydrogen. Woolworths currently offers several hydrogen water products, including Boundless Kids Hydrogen Water, Boundless Detox Hydrogen Water, and Boundless Sport Hydrogen Water, each targeting different consumer segments with specific claims.

While the availability of hydrogen water at major retailers like Woolworths has increased its accessibility to Australian consumers, it's important to approach the claimed benefits with a critical eye. The scientific community is still investigating the potential effects of hydrogen-rich water on human health, and more research is needed to substantiate many of the marketing claims. This article will delve into the current state of scientific evidence, explore the technology behind hydrogen water production, and discuss important considerations for consumers interested in trying these products.

Here is the main body of the article on hydrogen water at Woolworths:

 

Introduction to Hydrogen Water at Woolworths

What is Hydrogen Water?

Hydrogen water refers to water that has been infused with molecular hydrogen (H2) gas. This process typically involves dissolving hydrogen gas into purified water through methods such as electrolysis or nanobubble infusion technology (Ohta, 2011). The resulting product contains dissolved hydrogen molecules and is claimed to have potential health benefits due to hydrogen's purported antioxidant and anti-inflammatory properties.

The concept of hydrogen-rich water for health purposes emerged from research in Japan in the early 2000s. Scientists began investigating the potential therapeutic effects of molecular hydrogen after observing that deep-sea divers breathing hydrogen-containing gas mixtures seemed to experience less decompression sickness (Dole et al., 1975). This led to further studies exploring hydrogen's biological effects, particularly its ability to selectively reduce harmful free radicals in the body.

Proponents of hydrogen water claim it may offer benefits such as reduced oxidative stress, decreased inflammation, improved athletic performance and recovery, enhanced hydration, and support for various health conditions. However, it's important to note that while some preliminary research shows promise, many of these purported benefits require further rigorous scientific study to be conclusively proven in humans.

The growing interest in hydrogen water has led to its increased availability in many countries, including Australia. Major retailers like Woolworths have begun stocking hydrogen water products to meet consumer demand for this trendy beverage. However, consumers should approach the claimed benefits with a critical eye and consult healthcare professionals for personalized health advice.

Hydrogen Water Products Available at Woolworths

Woolworths, one of Australia's leading supermarket chains, has embraced the hydrogen water trend by offering a range of products under the Boundless brand. These products are designed to cater to different consumer segments and lifestyle needs. The current lineup of hydrogen water products available at Woolworths includes:

  1. Boundless Kids Hydrogen Water (24 Pack): This product is marketed specifically for children, with claims of supporting hydration and overall health. The packaging emphasizes that it contains no preservatives, sweeteners, or additives, and has zero calories per serving.

  2. Boundless Detox Hydrogen Water (24 Pack): Aimed at busy professionals, parents, and students, this product is positioned as a way to support hydration, detoxification, and general wellbeing. Like the kids' version, it contains zero calories per serving.

  3. Boundless Sport Hydrogen Water (24 Pack): Formulated for athletes and active individuals, this product claims to enhance performance, improve recovery, and aid hydration. It reportedly contains 10 parts per million (PPM) of hydrogen and also has zero calories per serving.

These products are typically sold in convenient 24-pack cases, making them easily accessible for regular consumption. The availability of hydrogen water at a major retailer like Woolworths has significantly increased its visibility and accessibility to Australian consumers.

It's worth noting that while these products make various claims about potential benefits, the scientific evidence supporting these claims is still evolving. Consumers should be aware that the regulatory status of hydrogen water and the substantiation required for health claims can vary between countries.

Boundless Hydrogen Water Product Line

Boundless Kids Hydrogen Water

Boundless Kids Hydrogen Water is a product specifically formulated and marketed for children. This product aims to provide a novel hydration option for parents looking to support their children's health and wellbeing. The key features of this product, as advertised by Woolworths, include:

  1. Zero calories: The product contains no added sugars or sweeteners, making it a calorie-free beverage option for children.

  2. No preservatives or additives: The water is marketed as pure and free from artificial additives, appealing to parents concerned about minimizing their children's exposure to synthetic ingredients.

  3. Hydrogen infusion: The water is infused with molecular hydrogen, which is claimed to provide potential health benefits.

While the product is marketed towards children, it's important to note that the effects of regular hydrogen water consumption on developing bodies have not been extensively studied. Parents should approach such products with caution and consult with pediatricians or healthcare professionals before incorporating them into their children's diets.

The potential benefits claimed for children consuming hydrogen water are largely extrapolated from general hydrogen water research, which has primarily been conducted on adults or in laboratory settings. Some proponents suggest that the antioxidant properties of hydrogen might support overall health and potentially aid in issues like allergies or inflammation. However, these claims require further scientific validation, especially in pediatric populations.

It's crucial to emphasize that while hydrogen water may be marketed as a health-promoting beverage, it should not replace regular water in a child's diet. Proper hydration with plain water remains essential for children's health and development.

Boundless Detox Hydrogen Water

Boundless Detox Hydrogen Water is marketed towards busy professionals, parents, and students as a product to support hydration, detoxification, and overall wellbeing. The key features of this product, as advertised by Woolworths, include:

  1. Zero calories: Like the kids' version, this product contains no added sugars or calories.

  2. Hydrogen infusion: The water is infused with molecular hydrogen, which is claimed to have detoxifying properties.

  3. Convenience: The product is packaged for on-the-go consumption, catering to busy lifestyles.

The term "detox" in the product name suggests potential benefits related to the body's natural detoxification processes. However, it's important to note that the body has its own sophisticated detoxification systems, primarily involving the liver and kidneys. The scientific evidence supporting the need for external "detoxification" through specific foods or beverages is limited.

Some studies have investigated the potential effects of hydrogen-rich water on oxidative stress and inflammation, which are sometimes associated with the concept of "detoxification" in popular health discourse. For example, a study by Nakao et al. (2010) found that consuming hydrogen-rich water decreased oxidative stress in patients with metabolic syndrome. However, more research is needed to conclusively establish the effects of hydrogen water on detoxification processes in healthy individuals.

It's crucial for consumers to understand that while hydrogen water may have potential benefits, it should not be seen as a replacement for a balanced diet, regular exercise, adequate sleep, and other lifestyle factors that support the body's natural detoxification processes. Additionally, individuals with specific health concerns should consult with healthcare professionals before relying on any product for detoxification purposes.

Boundless Sport Hydrogen Water

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Boundless Sport Hydrogen Water is specifically formulated and marketed for athletes and active individuals. This product claims to enhance performance, improve recovery, and aid hydration. The key features of this product, as advertised by Woolworths, include:

  1. High hydrogen concentration: The product reportedly contains 10 parts per million (PPM) of hydrogen, which is claimed to be a significant amount for potential benefits.

  2. Zero calories: Like other products in the Boundless line, this sports version contains no added sugars or calories.

  3. Performance and recovery focus: The marketing emphasizes potential benefits for athletic performance and post-exercise recovery.

The potential benefits of hydrogen water for athletes have been a subject of scientific interest. Some studies have investigated the effects of hydrogen-rich water on exercise-induced oxidative stress and inflammation. For instance, a study by Aoki et al. (2012) found that soccer players who consumed hydrogen-rich water before exercise showed lower blood lactate levels and improved exercise-induced decline of muscle function.

Another study by Kawamura et al. (2020) examined the effects of hydrogen water on muscle fatigue and function in young athletes. The researchers found that consuming hydrogen water before exercise led to lower levels of blood lactate and improved muscle function compared to placebo.

However, it's important to note that while these studies show promising results, the body of evidence is still limited, and more extensive research is needed to conclusively establish the benefits of hydrogen water for athletic performance and recovery.

Athletes considering incorporating hydrogen water into their hydration strategy should keep in mind that it should not replace proven hydration methods or a balanced diet. Proper hydration with regular water, along with appropriate electrolyte balance, remains crucial for athletic performance and recovery.

The Science Behind Hydrogen Water

Molecular Hydrogen and Its Potential Effects

Molecular hydrogen (H2) is the smallest and lightest molecule in the universe, consisting of two hydrogen atoms. Its small size and neutral charge allow it to diffuse rapidly through cell membranes, potentially reaching various compartments within cells, including mitochondria and nuclei (Ohta, 2011).

The primary mechanism by which molecular hydrogen is thought to exert its effects is through its antioxidant properties. Unlike other antioxidants, hydrogen is believed to selectively reduce cytotoxic oxygen radicals, particularly the hydroxyl radical (•OH), while maintaining the important signaling functions of other reactive oxygen species (ROS) (Ohsawa et al., 2007).

This selective antioxidant action is significant because while some level of oxidative stress is necessary for normal cellular functions, excessive oxidative stress can lead to cellular damage and contribute to various pathological conditions. By potentially reducing harmful oxidative stress without interfering with beneficial oxidative signaling, hydrogen may offer unique therapeutic potential.

In addition to its direct antioxidant effects, some research suggests that hydrogen may also have indirect antioxidant effects by upregulating antioxidant enzymes and cytoprotective proteins through activation of the Nrf2-Keap1 system (Iketani et al., 2017). This system plays a crucial role in cellular defense against oxidative stress.

Research on Hydrogen Water and Health

The potential health effects of hydrogen water have been the subject of numerous studies, although many have been conducted in animal models or small-scale human trials. Here's an overview of some key areas of research:

  1. Metabolic Syndrome: A study by Nakao et al. (2010) found that consuming hydrogen-rich water for 8 weeks led to improvements in markers of metabolic syndrome in 20 subjects. The researchers observed decreases in total cholesterol and LDL-cholesterol levels, as well as improvements in glucose metabolism.

  2. Parkinson's Disease: A pilot study by Yoritaka et al. (2013) involving 17 patients with Parkinson's disease found that drinking hydrogen water for 48 weeks led to improved scores on the Unified Parkinson's Disease Rating Scale. However, the authors noted that larger-scale studies are needed to confirm these findings.

  3. Rheumatoid Arthritis: Ishibashi et al. (2012) conducted a study with 20 patients with rheumatoid arthritis and found that drinking hydrogen water for 4 weeks led to improvements in disease activity scores. Again, the authors emphasized the need for larger studies to validate these results.

  4. Athletic Performance: As mentioned earlier, studies by Aoki et al. (2012) and Kawamura et al. (2020) have shown potential benefits of hydrogen water consumption on exercise-induced oxidative stress and muscle function in athletes.

While these studies show promising results, it's crucial to note that much of the research on hydrogen water is still in its early stages. Many studies have small sample sizes or have been conducted primarily in animal models. Larger, well-designed human clinical trials are needed to conclusively establish the health benefits of hydrogen water.

Oxidative Stress and Free Radicals

Oxidative stress occurs when there's an imbalance between the production of reactive oxygen species (ROS) and the body's ability to counteract their harmful effects through neutralization by antioxidants. Free radicals, which are a type of ROS, are unstable molecules that can damage cellular components such as DNA, proteins, and lipids.

While some level of ROS is necessary for normal cellular functions, including signaling and immune responses, excessive levels can lead to oxidative stress. This state has been implicated in various pathological conditions, including cardiovascular diseases, neurodegenerative disorders, and certain types of cancer (Pizzino et al., 2017).

Hydrogen water is proposed to help combat oxidative stress by providing a source of molecular hydrogen, which can act as a selective antioxidant. The key word here is "selective" - while many antioxidants neutralize all types of ROS indiscriminately, hydrogen is thought to primarily target the most cytotoxic ROS, such as the hydroxyl radical, while leaving other ROS that have important signaling functions relatively untouched (Ohta, 2011).

This selective action is important because complete elimination of ROS could potentially interfere with normal cellular processes. By targeting only the most harmful ROS, hydrogen might offer a way to reduce oxidative damage without disrupting beneficial oxidative signaling pathways.

However, it's important to note that while the theoretical basis for hydrogen's antioxidant action is sound, more research is needed to fully understand how this translates to real-world health benefits in humans consuming hydrogen water.

Potential Effects on Inflammation

Inflammation is a complex biological response to harmful stimuli, such as pathogens, damaged cells, or irritants. While acute inflammation is a necessary part of the body's healing process, chronic inflammation has been linked to various health issues, including cardiovascular diseases, diabetes, and certain types of cancer (Furman et al., 2019).

Some research suggests that molecular hydrogen may have anti-inflammatory effects. The proposed mechanisms include:

  1. Modulation of inflammatory cytokines: Studies have shown that hydrogen treatment can reduce the levels of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, while increasing anti-inflammatory cytokines like IL-10 (Ohta, 2011).

  2. Regulation of inflammatory signaling pathways: Hydrogen has been shown to modulate various signaling pathways involved in inflammation, including NF-κB and NLRP3 inflammasome pathways (Qian et al., 2017).

  3. Reduction of oxidative stress-induced inflammation: By reducing oxidative stress, hydrogen may indirectly decrease inflammation, as oxidative stress and inflammation are closely linked (Ohta, 2011).

For example, a study by Ishibashi et al. (2012) on patients with rheumatoid arthritis, an inflammatory condition, found that drinking hydrogen water for 4 weeks led to improvements in disease activity scores. However, the authors noted that larger studies are needed to confirm these findings.

Another study by Xia et al. (2013) in a mouse model of inflammatory bowel disease found that hydrogen-rich saline reduced inflammation and oxidative stress in the colon.

While these results are promising, it's important to note that much of the research on hydrogen's anti-inflammatory effects has been conducted in animal models or small-scale human studies. Larger, well-designed clinical trials are needed to conclusively establish the anti-inflammatory effects of hydrogen water in humans and its potential therapeutic applications.

Hydrogen Water and Athletic Performance

The potential benefits of hydrogen water for athletic performance and recovery have garnered significant interest in recent years. The proposed mechanisms by which hydrogen water might benefit athletes include:

  1. Reduction of exercise-induced oxidative stress: Intense exercise can lead to increased production of reactive oxygen species (ROS), potentially causing oxidative damage. Hydrogen's antioxidant properties might help mitigate this exercise-induced oxidative stress (Aoki et al., 2012).

  2. Improved muscle function and reduced fatigue: Some studies suggest that hydrogen water consumption might help maintain muscle function and reduce fatigue during and after exercise (Kawamura et al., 2020).

  3. Enhanced recovery: By potentially reducing inflammation and oxidative stress, hydrogen water might aid in post-exercise recovery (Ostojic, 2014).

Several studies have investigated these potential benefits:

  1. Aoki et al. (2012) conducted a study on elite soccer players and found that those who consumed hydrogen-rich water before exercise showed lower blood lactate levels and improved exercise-induced decline of muscle function compared to those who consumed placebo water.

  2. Kawamura et al. (2020) examined the effects of hydrogen water on muscle fatigue and function in young athletes. The researchers found that consuming hydrogen water before exercise led to lower levels of blood lactate and improved muscle function compared to placebo.

  3. A study by Ostojic et al. (2011) on male athletes found that drinking hydrogen-rich water for two weeks reduced blood lactate levels during maximal exercise and improved exercise-induced decline of muscle function.

While these studies show promising results, it's important to note that the research in this area is still in its early stages. Many studies have small sample sizes, and more extensive, long-term research is needed to conclusively establish the benefits of hydrogen water for athletic performance and recovery.

Moreover, it's crucial to emphasize that hydrogen water should not be seen as a replacement for proven hydration strategies or a balanced diet. Proper hydration with regular water, along with appropriate nutrition and training, remains fundamental for athletic performance and recovery.

Hydrogen Water Technology

Methods of Hydrogen Infusion

Several methods are used to infuse water with hydrogen, each with its own advantages and limitations:

  1. Electrolysis: This is one of the most common methods used in commercial hydrogen water products. It involves passing an electric current through water to split water molecules into hydrogen and oxygen. The hydrogen gas is then dissolved into the water. Some devices use technologies like Solid Polymer Electrolyte (SPE) or Proton-Exchange Membrane (PEM) to enhance this process (Shirahata et al., 2012).

  2. Magnesium Reaction: This method involves using magnesium metal to react with water, producing hydrogen gas. While this can be an effective method, it can potentially introduce magnesium ions into the water, which may not be desirable for all consumers (Ohno et al., 2012).

  3. Hydrogen Gas Infusion: In this method, pure hydrogen gas is bubbled through water under pressure. This can produce high concentrations of dissolved hydrogen but requires careful handling of hydrogen gas (Kurokawa et al., 2015).

4.

Conclusion

The emergence of hydrogen water products at Woolworths reflects a growing consumer interest in functional beverages and potential health-enhancing supplements. While the theoretical basis for hydrogen's antioxidant properties is sound, the practical implications for human health through hydrogen water consumption require further investigation.

Current research on hydrogen water shows promise in several areas, including potential benefits for metabolic syndrome, certain neurological conditions, and exercise-induced oxidative stress. However, it's crucial to note that much of this research is still in its early stages, often involving small sample sizes or animal models. Larger, well-designed human clinical trials are necessary to conclusively establish the health benefits of hydrogen water consumption.

For consumers considering hydrogen water products available at Woolworths, it's important to approach these beverages with realistic expectations. While they may offer potential benefits, hydrogen water should not be viewed as a miracle cure or a replacement for a balanced diet, regular exercise, and proper hydration with plain water. The relatively high cost of hydrogen water compared to regular water is also a factor to consider.

It's also worth noting that the regulatory status of hydrogen water and the claims that can be made about its benefits vary between countries. In Australia, the Therapeutic Goods Administration (TGA) has strict guidelines about health claims for food and beverage products. Consumers should be aware that many of the benefits suggested in marketing materials may not have been officially recognized or approved by regulatory bodies.

As research in this field continues to evolve, we may gain a clearer understanding of the potential role of hydrogen water in health and wellness. For now, individuals interested in trying hydrogen water products from Woolworths should do so as part of a balanced approach to health, rather than relying on them as a primary health intervention. As always, it's advisable to consult with healthcare professionals before making significant changes to one's diet or supplement regimen, especially for those with existing health conditions.

In conclusion, while hydrogen water represents an intriguing development in the beverage industry, more research is needed to fully understand its effects on human health. As consumers, it's important to stay informed about the latest scientific findings and approach new health trends with a balanced perspective.

 

 

 

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Ostojic, S. M. (2014). Molecular hydrogen in sports medicine: new therapeutic perspectives. International Journal of Sports Medicine, 35(12), 1010-1015.

Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., ... & Bitto, A. (2017). Oxidative stress: harms and benefits for human health. Oxidative Medicine and Cellular Longevity, 2017.

Qian, L., Shen, J., Chuai, Y., & Cai, J. (2013). Hydrogen as a new class of radioprotective agent. International Journal of Biological Sciences, 9(9), 887-894.

Shirahata, S., Hamasaki, T., & Teruya, K. (2012). Advanced research on the health benefit of reduced water. Trends in Food Science & Technology, 23(2), 124-131.

Xia, C., Liu, W., Zeng, D., Zhu, L., Sun, X., & Sun, X. (2013). Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B. Clinical and Translational Science, 6(5), 372-375.

Yoritaka, A., Takanashi, M., Hirayama, M., Nakahara, T., Ohta, S., & Hattori, N. (2013). Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial. Movement Disorders, 28(6), 836-839.

Key Highlights and Actionable Tips

  • Hydrogen water is water infused with molecular hydrogen (H2), claimed to have antioxidant properties and potential health benefits.
  • Woolworths offers a range of hydrogen water products under the Boundless brand, including options for kids, detox, and sports.
  • The scientific evidence supporting hydrogen water's health claims is still evolving, with many studies being small-scale or conducted on animal models.
  • Hydrogen water may have potential benefits for reducing oxidative stress, inflammation, and improving athletic performance, but more research is needed.
  • Consumers should approach hydrogen water products with realistic expectations and not view them as a replacement for a balanced diet and regular exercise.
  • Consult with healthcare professionals before incorporating hydrogen water into your routine, especially if you have existing health conditions.
  • Be aware that regulatory bodies like the TGA have strict guidelines about health claims for food and beverage products.
  • Consider the cost of hydrogen water compared to regular water when making purchasing decisions.
  • Stay informed about the latest scientific findings regarding hydrogen water and its potential effects on health.

How does the hydrogen concentration in Boundless Sport Hydrogen Water compare to other brands?

Boundless Sport Hydrogen Water reportedly contains 10 parts per million (PPM) of hydrogen. While this is a significant amount, it's difficult to make direct comparisons with other brands without specific data. Hydrogen concentrations can vary widely between products and may depend on the production method and packaging. It's important to note that higher concentrations don't necessarily equate to better results, as the optimal concentration for health benefits is still being researched.

Are there any potential side effects or risks associated with drinking hydrogen water regularly?

Current research suggests that hydrogen water is generally safe for consumption. However, as with any new dietary addition, some individuals may experience mild digestive discomfort initially. There's no evidence of toxicity from consuming hydrogen water, even at high concentrations. However, long-term effects of regular consumption have not been extensively studied. It's always advisable to consult with a healthcare professional before making significant changes to your diet or hydration routine, especially if you have pre-existing health conditions.

How long does the hydrogen content in Boundless hydrogen water products remain stable after opening?

The stability of hydrogen in water can be a challenge, as hydrogen gas can escape over time. Once a bottle of hydrogen water is opened, the hydrogen content may begin to decrease. While exact figures for Boundless products aren't provided, generally, it's recommended to consume hydrogen water soon after opening to ensure maximum potential benefits. Some manufacturers suggest consuming the product within 30 minutes to an hour of opening for optimal hydrogen content.

Can hydrogen water be used in cooking or to make other beverages, and would it retain its potential benefits?

Hydrogen water can technically be used in cooking or to make other beverages, but it's likely that much of the hydrogen content would be lost in the process, especially if heat is involved. Hydrogen is a volatile gas that easily escapes from water, particularly when heated or agitated. Therefore, using hydrogen water in cooking or as a base for other drinks may not retain the potential benefits associated with consuming it directly. For maximum potential benefit, it's generally recommended to drink hydrogen water as is, without mixing or heating.

How does the environmental impact of bottled hydrogen water compare to regular bottled water?

The environmental impact of bottled hydrogen water is likely similar to that of regular bottled water in terms of plastic waste and transportation emissions. However, the production of hydrogen water requires additional energy for the hydrogen infusion process, which could potentially increase its carbon footprint compared to regular bottled water. Some hydrogen water brands may use more environmentally friendly packaging or production methods, but this varies by manufacturer. As with all bottled beverages, the most environmentally friendly option is to use reusable bottles and drink tap water where safe and available. If choosing bottled hydrogen water, consider recycling the bottles and looking for brands with sustainable practices.

References (Click to Expand)

Aoki, K., Nakao, A., Adachi, T., Matsui, Y., & Miyakawa, S. (2012). Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Medical Gas Research, 2(1), 12.

Dole, M., Wilson, F. R., & Fife, W. P. (1975). Hyperbaric hydrogen therapy: a possible treatment for cancer. Science, 190(4210), 152-154.

Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., ... & Slavich, G. M. (2019). Chronic inflammation in the etiology of disease across the life span. Nature Medicine, 25(12), 1822-1832.

Iketani, M., Ohsawa, I., Takahashi, K., Tanaka, Y., Sato, Y., Yamaguchi, K., ... & Ohta, S. (2017). Nrf2 activation protects against renal ischemia-reperfusion injury through suppression of endoplasmic reticulum stress. Free Radical Biology and Medicine, 106, 120-131.

Ishibashi, T., Sato, B., Rikitake, M., Seo, T., Kurokawa, R., Hara, Y., ... & Nagao, T. (2012). Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Medical Gas Research, 2(1), 27.

Kawamura, T., Gando, Y., Takahashi, M., Hara, R., Suzuki, K., & Muraoka, I. (2020). Effects of hydrogen bathing on exercise-induced oxidative stress and delayed-onset muscle soreness. Japanese Journal of Physical Fitness and Sports Medicine, 69(1), 39-52.

Kurokawa, R., Seo, T., Sato, B., Hirano, S. I., & Sato, F. (2015). Convenient methods for ingestion of molecular hydrogen: drinking, injection, and inhalation. Medical Gas Research, 5(1), 13.

Nakao, A., Toyoda, Y., Sharma, P., Evans, M., & Guthrie, N. (2010). Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome—an open label pilot study. Journal of Clinical Biochemistry and Nutrition, 46(2), 140-149.

Ohno, K., Ito, M., Ichihara, M., & Ito, M. (2012). Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxidative Medicine and Cellular Longevity, 2012.

Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., ... & Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 13(6), 688-694.

Ohta, S. (2011). Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications. Current Pharmaceutical Design, 17(22), 2241-2252.

Ostojic, S. M. (2014). Molecular hydrogen in sports medicine: new therapeutic perspectives. International Journal of Sports Medicine, 35(12), 1010-1015.

Ostojic, S. M., Stojanovic, M. D., Calleja-Gonzalez, J., Obrenovic, M. D., Veljovic, D., Medjedovic, B., ... & Stajer, V. (2011). Drinking hydrogen-rich water for 4 weeks positively affects serum antioxidant enzymes in healthy men: a pilot study. Current Topics in Nutraceutical Research, 9(1/2), 31.

Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., ... & Bitto, A. (2017). Oxidative stress: harms and benefits for human health. Oxidative Medicine and Cellular Longevity, 2017.

Qian, L., Shen, J., Chuai, Y., & Cai, J. (2013). Hydrogen as a new class of radioprotective agent. International Journal of Biological Sciences, 9(9), 887-894.

Shirahata, S., Hamasaki, T., & Teruya, K. (2012). Advanced research on the health benefit of reduced water. Trends in Food Science & Technology, 23(2), 124-131.

Xia, C., Liu, W., Zeng, D., Zhu, L., Sun, X., & Sun, X. (2013). Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B. Clinical and Translational Science, 6(5), 372-375.

Yoritaka, A., Takanashi, M., Hirayama, M., Nakahara, T., Ohta, S., & Hattori, N. (2013). Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial. Movement Disorders, 28(6), 836-839.

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