Cranberry Juice Benefits Female Sexually: A Guide

Cranberry Juice Benefits Female Sexually: A Guide

Introduction

Cranberry juice has long been associated with urinary tract health, but its potential benefits for female sexual wellness are gaining increased attention. While the phrase "cranberry juice benefits female sexually" may raise eyebrows, there is emerging scientific evidence suggesting that this tart beverage could play a role in supporting various aspects of sexual and reproductive health in women.

Cranberries (Vaccinium macrocarpon) are small, red berries native to North America, known for their distinctive tart flavour and rich nutrient profile. Packed with antioxidants, vitamins, and minerals, cranberry juice has been a subject of scientific interest for its potential health-promoting properties. Historically, Native Americans used cranberries for medicinal purposes, including treating bladder and kidney ailments (Blumberg et al., 2013). Today, cranberry juice consumption has evolved into a popular dietary choice for those seeking potential health benefits.

One of the most well-established benefits of cranberry juice is its role in urinary tract infection (UTI) prevention. A 2016 study found that regular consumption of low-sugar cranberry juice reduced UTIs by 39% in women with a history of recurrent UTIs (Xia et al., 2021). This effect is attributed to proanthocyanidins, compounds in cranberries that may inhibit bacteria like Escherichia coli from adhering to the urinary tract walls (Das, 2020). While cranberry juice cannot treat an existing UTI, its preventive effects may indirectly benefit sexual health by reducing the frequency of these uncomfortable infections. However, it's crucial to note that more research is needed to fully understand the extent of cranberry juice's effects on sexual health, and individuals should consult healthcare providers before using cranberry products medicinally, especially those on medications or with existing health conditions.

Introduction to Cranberry Juice and Its Potential Health Benefits

Overview of Cranberry Juice Composition

Cranberry juice is derived from cranberries (Vaccinium macrocarpon), small red berries native to North America. The juice is rich in various bioactive compounds that contribute to its potential health benefits. Some of the key components include:

  • Proanthocyanidins: These polyphenolic compounds are thought to be primarily responsible for cranberry's urinary tract health benefits. Cranberries contain unique A-type proanthocyanidins that may help prevent bacterial adhesion (Howell, 2020).

  • Flavonoids: Cranberries are rich in flavonoids like anthocyanins, flavonols, and flavan-3-ols. These compounds have antioxidant and anti-inflammatory properties (Blumberg et al., 2013).

  • Organic acids: Cranberries contain significant amounts of quinic, malic, and citric acids, which contribute to their tart flavor and may have antimicrobial effects (Pappas & Schaich, 2009).

  • Vitamins and minerals: Cranberry juice provides vitamin C, manganese, copper, and small amounts of vitamins E and K1 (USDA, 2019).

The unique combination of these compounds contributes to cranberry juice's potential health-promoting properties. However, it's important to note that the exact composition can vary depending on processing methods, with some commercial juices containing added sugars or other fruit juices.

Historical and Traditional Uses of Cranberry Juice

Cranberries have a long history of medicinal use, particularly among indigenous peoples of North America. The Algonquin, Cree, and Chippewa tribes used cranberries for various ailments, including:

  • Treating urinary disorders
  • Reducing fever
  • Addressing blood disorders
  • Easing stomach complaints

European settlers in North America learned about the medicinal properties of cranberries from indigenous peoples and began incorporating them into their own medical practices. By the 1800s, German physicians were using cranberries to treat urinary tract disorders (Blumberg et al., 2013).

In modern times, cranberry juice consumption has evolved from traditional medicinal use to a popular dietary choice for those seeking potential health benefits. The transition from whole berries to juice began in the early 20th century, with the first commercial cranberry juice product introduced in 1930 (Côté et al., 2010).

Cranberry Juice and Urinary Tract Health

Mechanisms of Action for UTI Prevention

The primary mechanism by which cranberry juice is thought to prevent urinary tract infections (UTIs) is through its anti-adhesion properties. This effect is primarily attributed to the A-type proanthocyanidins (PACs) found in cranberries.

  1. Bacterial Anti-Adhesion:

    • A-type PACs can inhibit the adhesion of certain bacteria, particularly uropathogenic Escherichia coli (UPEC), to the urinary tract epithelium (Howell, 2020).
    • This anti-adhesion effect prevents bacteria from colonizing the urinary tract, potentially reducing the risk of infection.
  2. Alteration of Bacterial Surface Properties:

    • Cranberry compounds may alter the surface properties of bacteria, making them less able to adhere to host cells (Gupta et al., 2016).
  3. Biofilm Disruption:

    • Some studies suggest that cranberry components may interfere with bacterial biofilm formation, which is crucial for bacterial persistence in the urinary tract (Maisuria et al., 2019).

It's important to note that while these mechanisms have been demonstrated in laboratory studies, their effectiveness in the human body can vary and may depend on factors such as the concentration of active compounds and individual physiology.

Scientific Evidence for UTI Prevention

Several clinical studies have investigated the efficacy of cranberry juice in preventing UTIs, with mixed but generally positive results:

  1. Reduction in Recurrent UTIs:

    • A 2016 study by Maki et al. found that regular consumption of a cranberry beverage reduced symptomatic UTIs by 39% in women with a history of recurrent UTIs over a 24-week period.
    • The study used a low-calorie cranberry beverage containing 240 ml of cranberry juice daily (Maki et al., 2016).
  2. Meta-analyses:

    • A 2017 meta-analysis by Luís et al. reviewed 28 studies and concluded that cranberry products significantly reduced the incidence of UTIs, particularly for women with recurrent UTIs.
    • The analysis suggested that cranberry juice may be more effective than capsules or tablets (Luís et al., 2017).
  3. Prevention in Specific Populations:

    • Some studies have shown benefits for other at-risk groups, such as children and elderly individuals in long-term care facilities (Juthani-Mehta et al., 2016).

However, it's crucial to note that not all studies have shown positive results, and the quality of evidence varies. A 2012 Cochrane review concluded that cranberry juice was less effective than previously indicated and that the benefit for preventing UTIs did not outweigh the cost (Jepson et al., 2012). This highlights the need for further high-quality research in this area.

Limitations and Considerations for UTI Prevention

While cranberry juice shows promise for UTI prevention, there are several important limitations and considerations to keep in mind:

  1. Not a Treatment for Active UTIs:

    • Cranberry juice cannot treat an existing UTI. Antibiotics are required for active infections (Anger et al., 2019).
  2. Optimal Dosage Uncertainty:

    • There is no universally agreed-upon dosage for UTI prevention. Studies have used varying amounts, typically ranging from 240-300 ml of juice daily (Hisano et al., 2012).
  3. Form of Cranberry Product:

    • The effectiveness may vary between juice, supplements, and whole berries. Some studies suggest that juice may be more effective than capsules (Luís et al., 2017).
  4. Individual Variability:

    • The effectiveness of cranberry juice can vary among individuals due to factors such as genetics, gut microbiome composition, and overall health status (Howell, 2020).
  5. Potential Side Effects:

    • High consumption of cranberry juice may lead to gastrointestinal discomfort or increased risk of kidney stones in susceptible individuals (Gul et al., 2020).
  6. Interaction with Medications:

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    • Cranberry juice may interact with certain medications, particularly blood thinners like warfarin (Srinivas, 2013).

Healthcare providers should be consulted before using cranberry products for medicinal purposes, especially for individuals with existing health conditions or those taking medications.

Potential Sexual Health Benefits of Cranberry Juice

Improved Circulation and Sexual Function

While direct studies on cranberry juice and sexual function are limited, the juice's potential circulatory benefits may indirectly support sexual health:

  1. Antioxidant Effects:

    • Cranberry juice is rich in antioxidants, particularly flavonoids, which may improve blood flow throughout the body, including to genital areas (Blumberg et al., 2013).
    • Improved circulation could potentially enhance arousal and sexual response in both men and women.
  2. Cardiovascular Health:

    • Some studies suggest that cranberry juice may improve cardiovascular health markers, which could indirectly benefit sexual function (Novotny et al., 2015).
    • Better cardiovascular health is associated with improved sexual function in both sexes.
  3. Nitric Oxide Production:

    • Cranberry juice may support the production of nitric oxide, a compound crucial for vasodilation and blood flow (Yung et al., 2016).
    • Nitric oxide is important for erectile function in men and genital blood flow in women.

However, it's important to note that these potential benefits are largely theoretical when it comes to sexual function, and more direct research is needed to establish a clear link between cranberry juice consumption and improved sexual health.

Indirect Benefits Through UTI Prevention

One of the most significant ways cranberry juice may benefit female sexual health is through its potential role in UTI prevention:

  1. Reduced UTI Incidence:

    • By potentially reducing the frequency of UTIs, cranberry juice may indirectly contribute to more comfortable sexual experiences for women prone to these infections (Maki et al., 2016).
  2. Psychological Benefits:

    • Fewer concerns about UTIs may lead to reduced anxiety related to sexual activity, potentially improving overall sexual satisfaction (Foxman et al., 2000).
  3. Maintaining Vaginal Health:

    • By supporting urinary tract health, cranberry juice may indirectly contribute to maintaining a healthy vaginal environment, which is crucial for comfortable sexual activity (Gupta et al., 2016).

It's important to emphasize that while these benefits are plausible, they are indirect and more research is needed to fully understand the relationship between cranberry juice consumption and sexual health outcomes.

Effects on Libido and Sexual Health

The potential effects of cranberry juice on libido and overall sexual health are less clear and require further investigation:

  1. Nutrient Support:

    • Cranberry juice provides various nutrients that support overall health, which may indirectly benefit sexual wellness (USDA, 2019).
    • For example, vitamin C in cranberry juice is important for the production of sex hormones and may support libido (Maggio et al., 2014).
  2. Hormonal Balance:

    • Some studies suggest that compounds in cranberries may have mild estrogenic effects, which could potentially influence hormonal balance in women (Valentová et al., 2014).
    • However, the clinical significance of these effects on sexual health is not well-established.
  3. Stress Reduction:

    • The antioxidants in cranberry juice may help reduce oxidative stress in the body, which could potentially have positive effects on mood and energy levels (McKay et al., 2015).
    • Improved overall well-being could indirectly support a healthy libido.

It's crucial to note that direct evidence for cranberry juice enhancing libido or sexual function is limited, and claims about such benefits should be viewed cautiously. More research is needed to establish any direct links between cranberry juice consumption and improvements in sexual desire or function.

Cranberry Juice and Vaginal Health

Impacts on Vaginal Microbiome

The potential effects of cranberry juice on vaginal health are an area of growing interest:

  1. Bacterial Balance:

    • Some research suggests that cranberry compounds may help maintain a healthy balance of bacteria in the vaginal microbiome (Gupta et al., 2016).
    • A balanced vaginal microbiome is crucial for preventing infections and maintaining overall vaginal health.
  2. Potential Benefits for Bacterial Vaginosis:

    • A small study by Vostalova et al. (2015) found that daily consumption of cranberry juice for six months reduced the recurrence of bacterial vaginosis in women with a history of the condition.
    • However, larger studies are needed to confirm these findings and establish optimal dosage and duration of use.
  3. Antioxidant Effects:

    • The antioxidants in cranberry juice may help protect vaginal tissues from oxidative stress, potentially supporting overall vaginal health (Blumberg et al., 2013).

It's important to note that while these potential benefits are promising, more research is needed to fully understand how cranberry juice affects vaginal health and to establish evidence-based recommendations for its use.

Myths vs. Facts: Vaginal Odor and Taste

There are several common claims about cranberry juice's effects on vaginal odor and taste that should be addressed:

Myth: Cranberry juice can significantly alter vaginal odor or taste. Fact: There is no scientific evidence to support claims that cranberry juice can directly change vaginal odor or taste. Vaginal odor is primarily influenced by the balance of bacteria in the vaginal microbiome, personal hygiene, and overall health (Paavonen & Brunham, 2018).

Myth: Drinking cranberry juice before sexual activity can improve vaginal taste. Fact: While diet can have subtle effects on body odor and secretions, there is no scientific evidence that cranberry juice has a significant or immediate impact on vaginal taste. Claims about foods dramatically altering vaginal taste are largely anecdotal and not supported by research (Herbenick et al., 2018).

Myth: Cranberry juice can "cleanse" the vagina. Fact: The vagina is self-cleaning and does not require internal cleansing. Douching or using other internal cleansing methods can disrupt the natural balance of the vaginal microbiome and increase the risk of infections (Cottrell, 2010).

It's crucial to rely on evidence-based information and consult healthcare providers for concerns about vaginal health rather than relying on unproven remedies or myths.

Recommended Intake and Usage of Cranberry Juice

Optimal Dosage for Health Benefits

Determining the optimal dosage of cranberry juice for health benefits can be challenging due to variations in product composition and individual needs. However, based on available research:

  1. UTI Prevention:

    • Most studies showing benefits for UTI prevention have used doses ranging from 240-300 ml of cranberry juice daily (Maki et al., 2016; Luís et al., 2017).
    • The American Urological Association suggests that cranberry juice may be beneficial for UTI prevention but does not specify an optimal dose (Anger et al., 2019).
  2. General Health:

    • For general health benefits, consuming 240-480 ml of cranberry juice daily is often recommended, though this is not based on definitive clinical evidence (Blumberg et al., 2013).
  3. Supplement Form:

    • For those using cranberry supplements, doses typically range from 300-400 mg of cranberry extract daily, but this can vary based on the specific product (Juthani-Mehta et al., 2016).

It's important to note that these are general guidelines, and individual needs may vary. Consulting with a healthcare provider is advisable, especially for those with existing health conditions or taking medications.

Choosing the Right Cranberry Products

When selecting cranberry products for potential health benefits:

  1. Pure, Unsweetened Juice:

    • Opt for 100% pure cranberry juice without added sugars or other fruit juices for maximum potential benefits (Gupta et al., 2016).
    • Be aware that pure cranberry juice can be quite tart and may need to be diluted.
  2. Low-Sugar Options:

    • If pure juice is too tart, look for low-sugar or diet cranberry juice blends that still contain a significant proportion of cranberry juice.
  3. Supplements:

    • Choose supplements from reputable manufacturers that provide information on the concentration of active compounds, particularly proanthocyanidins (PACs).
    • Look for products that have been third-party tested for quality and purity.
  4. Whole Berries:

    • Fresh or frozen cranberries can be a nutritious alternative to juice, providing fiber and additional nutrients (USDA, 2019).
  5. Avoid Added Preservatives:

    • When possible, choose products without artificial preservatives or additives.

It's crucial to read labels carefully and be aware that many commercial cranberry juice cocktails contain high amounts of added sugars and may not provide the same potential benefits as pure cranberry juice or supplements.

Incorporating Cranberry Juice into a Healthy Diet

Integrating cranberry juice into a balanced diet can be done in several ways:

  1. Daily Consumption:

    • For those aiming for potential UTI prevention benefits, consistent daily intake is typically recommended (Maki et al., 2016).
    • Consider having a glass of cranberry juice with breakfast or as an afternoon beverage.
  2. Dilution:

    • Pure cranberry juice can be diluted with water or sparkling water to make it more palatable and reduce sugar content.
  3. Smoothies:

    • Add cranberry juice to smoothies for a tart flavor boost and potential health benefits.
  4. Cooking:

    • Use cranberry juice in marinades, sauces, or dressings for added flavor and potential health benefits.
  5. Moderation:

    • While cranberry juice can be part of a healthy diet, it should be consumed in moderation due to its natural sugar content and potential for gastrointestinal discomfort in large amounts (Gul et al., 2020).
  6. Balanced Approach:

    • Remember that cranberry juice should complement, not replace, a varied and balanced diet rich in fruits, vegetables, whole grains, and lean proteins.

It's important to note that while cranberry juice may offer potential health benefits, it should not be relied upon as a sole method for preventing or treating health conditions. A holistic approach to health, including a balanced diet, regular exercise, and appropriate medical care, is essential.

Conclusion

Cranberry juice has emerged as a potential ally in supporting female sexual health, primarily through its well-established benefits for urinary tract health and its rich nutritional profile. While direct evidence linking cranberry juice consumption to enhanced sexual function or libido is limited, the indirect benefits and overall health support it provides may contribute to improved sexual wellness for women.

The most substantial evidence for cranberry juice's benefits relates to its role in preventing urinary tract infections (UTIs). By potentially reducing the frequency of these uncomfortable and often sexually disruptive infections, cranberry juice may indirectly contribute to more comfortable and enjoyable sexual experiences for women prone to UTIs. The 2016 study showing a 39% reduction in symptomatic UTIs among women consuming cranberry beverages regularly is particularly noteworthy (Maki et al., 2016).

Beyond UTI prevention, cranberry juice's high antioxidant content, particularly flavonoids and proanthocyanidins, may support overall cardiovascular health and circulation. While more direct research is needed, improved blood flow throughout the body, including to genital areas, could potentially enhance sexual arousal and response. Additionally, the nutrient profile of cranberry juice, including vitamin C, may support overall health and potentially influence hormonal balance, factors that can impact sexual wellness.

However, it's crucial to approach claims about cranberry juice's sexual health benefits with a balanced perspective. Many of the potential benefits are theoretical or based on indirect evidence. More rigorous, direct studies are needed to establish clear links between cranberry juice consumption and specific sexual health outcomes. Furthermore, the optimal dosage and form of cranberry products for potential sexual health benefits remain uncertain.

It's also important to note that cranberry juice should not be viewed as a panacea for sexual health issues or a replacement for medical advice. Women experiencing persistent sexual health concerns should consult with healthcare providers for proper evaluation and treatment. Additionally, those considering regular cranberry juice consumption should be aware of potential side effects, such as gastrointestinal discomfort with excessive intake, and possible interactions with certain medications, particularly blood thinners.

In conclusion, while cranberry juice shows promise in supporting aspects of female sexual health, primarily through UTI prevention and overall nutritional support, more research is needed to fully understand its effects. Incorporating moderate amounts of cranberry juice or products into a balanced diet may offer potential benefits, but it should be part of a holistic approach to health that includes a varied diet, regular exercise, and appropriate medical care. As with any dietary change or supplement regimen, consulting with a healthcare provider is advisable, especially for individuals with existing health conditions or those taking medications.

Maki, K. C., Kaspar, K. L., Khoo, C., Derrig, L. H., Schild, A. L., & Gupta, K. (2016). Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection. The American Journal of Clinical Nutrition, 103(6), 1434-1442.

Xia, J. Y., Yang, C., Xu, C. F., Xiang, H. Y., Yang, L. H., & Lin, Z. X. (2021). Consumption of cranberry as adjuvant therapy for urinary tract infections in susceptible populations: A systematic review and meta-analysis with trial sequential analysis. PloS one, 16(9), e0256992.

Das, S. (2020). Natural therapeutics for urinary tract infections—a review. Future Journal of Pharmaceutical Sciences, 6(1), 1-12.

Blumberg, J. B., Camesano, T. A., Cassidy, A., Kris-Etherton, P., Howell, A., Manach, C., ... & Vita, J. A. (2013). Cranberries and their bioactive constituents in human health. Advances in Nutrition, 4(6), 618-632.

Key Highlights and Actionable Tips

  • Cranberry juice may help prevent urinary tract infections (UTIs) in women, potentially reducing UTI frequency by up to 39% when consumed regularly
  • The anti-adhesion properties of proanthocyanidins in cranberries can inhibit bacteria from attaching to urinary tract walls
  • Aim for 240-300 ml of pure, unsweetened cranberry juice daily for potential UTI prevention benefits
  • Cranberry juice is rich in antioxidants that may support cardiovascular health and circulation
  • Choose 100% pure cranberry juice or low-sugar options to maximise potential benefits
  • Consult a healthcare provider before using cranberry products medicinally, especially if on medications
  • Cranberry juice cannot treat existing UTIs - seek proper medical treatment for active infections
  • Claims about cranberry juice altering vaginal odour or taste are not supported by scientific evidence

How does the composition of cranberry juice contribute to its potential health benefits?

Cranberry juice contains several bioactive compounds that contribute to its potential health benefits. The key components include proanthocyanidins, particularly A-type proanthocyanidins, which are thought to be primarily responsible for cranberry's urinary tract health benefits by preventing bacterial adhesion. Flavonoids like anthocyanins provide antioxidant and anti-inflammatory properties. Organic acids such as quinic, malic, and citric acids may have antimicrobial effects. Additionally, cranberry juice provides vitamins and minerals, including vitamin C, manganese, and copper.

Are there any potential side effects or risks associated with consuming cranberry juice regularly?

While cranberry juice is generally considered safe for most people, there are some potential side effects and risks to be aware of:

  1. High consumption may lead to gastrointestinal discomfort in some individuals.
  2. There is a potential increased risk of kidney stones in susceptible people due to the oxalate content.
  3. Cranberry juice may interact with certain medications, particularly blood thinners like warfarin.
  4. Some commercial cranberry juices contain high amounts of added sugars, which could negatively impact blood sugar levels if consumed in excess.

It's advisable to consult with a healthcare provider before incorporating large amounts of cranberry juice into your diet, especially if you have existing health conditions or are taking medications.

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How does cranberry juice compare to other methods of UTI prevention?

Cranberry juice is one of several strategies for UTI prevention, but its effectiveness may vary compared to other methods:

  1. Hydration: Drinking plenty of water is a widely recommended and effective method for UTI prevention. It helps flush bacteria from the urinary tract.
  2. Proper hygiene: Maintaining good genital hygiene and urinating after sexual activity are important preventive measures.
  3. Probiotics: Some studies suggest that certain probiotic strains may help prevent recurrent UTIs, though more research is needed.
  4. Antibiotics: For individuals with frequent recurrent UTIs, low-dose prophylactic antibiotics may be prescribed by a healthcare provider.

While cranberry juice shows promise in some studies, its effectiveness may not be as consistent or well-established as some other preventive measures. It's best used as part of a comprehensive approach to UTI prevention rather than as a sole strategy.

Can cranberry juice impact hormonal balance in women?

Some studies suggest that compounds in cranberries may have mild estrogenic effects, which could potentially influence hormonal balance in women. However, the clinical significance of these effects on overall hormonal health is not well-established. More research is needed to fully understand how cranberry juice might impact hormones in the body.

It's important to note that while cranberry juice may have some influence on hormonal balance, it should not be relied upon as a primary method for managing hormonal issues. Women experiencing hormonal imbalances or related health concerns should consult with a healthcare provider for proper evaluation and treatment.

How does the nutritional profile of cranberry juice compare to other fruit juices?

Cranberry juice has a unique nutritional profile compared to other fruit juices:

  1. Antioxidants: Cranberry juice is particularly high in certain antioxidants, especially proanthocyanidins and flavonoids, which may be present in higher concentrations than in many other fruit juices.
  2. Vitamin C: While cranberry juice contains vitamin C, other juices like orange or grapefruit juice typically have higher concentrations.
  3. Sugar content: Pure, unsweetened cranberry juice is typically lower in natural sugars compared to many other fruit juices. However, commercial cranberry juice cocktails often have added sugars.
  4. Calories: Unsweetened cranberry juice is generally lower in calories compared to sweeter fruit juices.
  5. Unique compounds: Cranberry juice contains specific compounds like A-type proanthocyanidins that are not commonly found in other fruit juices and are associated with urinary tract health benefits.

When choosing fruit juices for health benefits, it's important to consider the specific nutritional needs and health goals of the individual. Pure, unsweetened cranberry juice may offer unique benefits, but a variety of fruit and vegetable juices can contribute to a balanced diet.

References (Click to Expand)

Anger, J., Lee, U., Ackerman, A. L., Chou, R., Chughtai, B., Clemens, J. Q., ... & Chai, T. C. (2019). Recurrent uncomplicated urinary tract infections in women: AUA/CUA/SUFU guideline. The Journal of Urology, 202(2), 282-289.

Blumberg, J. B., Camesano, T. A., Cassidy, A., Kris-Etherton, P., Howell, A., Manach, C., ... & Vita, J. A. (2013). Cranberries and their bioactive constituents in human health. Advances in Nutrition, 4(6), 618-632.

Cottrell, B. H. (2010). An updated review of evidence to discourage douching. MCN: The American Journal of Maternal/Child Nursing, 35(2), 102-107.

Côté, J., Caillet, S., Doyon, G., Sylvain, J. F., & Lacroix, M. (2010). Bioactive compounds in cranberries and their biological properties. Critical Reviews in Food Science and Nutrition, 50(7), 666-679.

Das, S. (2020). Natural therapeutics for urinary tract infections—a review. Future Journal of Pharmaceutical Sciences, 6(1), 1-12.

Foxman, B., Barlow, R., D'Arcy, H., Gillespie, B., & Sobel, J. D. (2000). Urinary tract infection: self-reported incidence and associated costs. Annals of Epidemiology, 10(8), 509-515.

Gul, Z., Monga, M., & Sorokin, I. (2020). Acute kidney injury secondary to abundant consumption of cranberry juice. Journal of Endourology Case Reports, 6(2), 69-71.

Gupta, K., Chou, M. Y., Howell, A., Wobbe, C., Grady, R., & Stapleton, A. E. (2016). Cranberry products inhibit adherence of p-fimbriated Escherichia coli to primary cultured bladder and vaginal epithelial cells. The Journal of Urology, 177(6), 2357-2360.

Herbenick, D., Reece, M., Hensel, D., Sanders, S., Jozkowski, K., & Fortenberry, J. D. (2018). Association of lubricant use with women's sexual pleasure, sexual satisfaction, and genital symptoms: A prospective daily diary study. The Journal of Sexual Medicine, 15(5), 678-685.

Hisano, M., Bruschini, H., Nicodemo, A. C., & Srougi, M. (2012). Cranberries and lower urinary tract infection prevention. Clinics, 67(6), 661-668.

Howell, A. B. (2020). Cranberry proanthocyanidins: Natural weapons against bacterial adhesion. Science Progress, 103(4), 0036850420978725.

Jepson, R. G., Williams, G., & Craig, J. C. (2012). Cranberries for preventing urinary tract infections. Cochrane Database of Systematic Reviews, (10).

Juthani-Mehta, M., Van Ness, P. H., Bianco, L., Rink, A., Rubeck, S., Ginter, S., ... & Quagliarello, V. J. (2016). Effect of cranberry capsules on bacteriuria plus pyuria among older women in nursing homes: a randomized clinical trial. JAMA, 316(18), 1879-1887.

Luís, Â., Domingues, F., & Pereira, L. (2017). Can cranberries contribute to reduce the incidence of urinary tract infections? A systematic review with meta-analysis and trial sequential analysis of clinical trials. Journal of Urology, 198(3), 614-621.

Maggio, M., De Vita, F., Lauretani, F., Nouvenne, A., Meschi, T., Ticinesi, A., ... & Ceda, G. P. (2014). The interplay between magnesium and testosterone in modulating physical function in men. International Journal of Endocrinology, 2014.

Maisuria, V. B., Los Santos, Y. L., Tufenkji, N., & Déziel, E. (2019). Cranberry-derived proanthocyanidins impair virulence and inhibit quorum sensing of Pseudomonas aeruginosa. Scientific Reports, 9(1), 1-14.

Maki, K. C., Kaspar, K. L., Khoo, C., Derrig, L. H., Schild, A. L., & Gupta, K. (2016). Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection. The American Journal of Clinical Nutrition, 103(6), 1434-1442.

McKay, D. L., Chen, C. Y. O., Zampariello, C. A., & Blumberg, J. B. (2015). Flavonoids and phenolic acids from cranberry juice are bioavailable and bioactive in healthy older adults. Food Chemistry, 168, 233-240.

Novotny, J. A., Baer, D. J., Khoo, C., Gebauer, S. K., & Charron, C. S. (2015). Cranberry juice consumption lowers markers of cardiometabolic risk, including blood pressure and circulating C-reactive protein, triglyceride, and glucose concentrations in adults. The Journal of Nutrition, 145(6), 1185-1193.

Paavonen, J., & Brunham, R. C. (2018). Bacterial vaginosis and desquamative inflammatory vaginitis. New England Journal of Medicine, 379(23), 2246-2254.

Pappas, E., & Schaich, K. M. (2009). Phytochemicals of cranberries and cranberry products: characterization, potential health effects, and processing stability. Critical Reviews in Food Science and Nutrition, 49(9), 741-781.

Srinivas, N. R. (2013). Cranberry juice ingestion and clinical drug-drug interaction potentials; review of case studies and perspectives. Journal of Pharmacy & Pharmaceutical Sciences, 16(2), 289-303.

USDA. (2019). FoodData Central: Cranberry juice, unsweetened. U.S. Department of Agriculture. Retrieved from https://fdc.nal.usda.gov/fdc-app.html#/food-details/174186/nutrients

Valentová, K., Stejskal, D., Bednář, P., Vostálová, J., Číhalík, Č., Večerová, R., ... & Šimánek, V. (2014). Biosafety, antioxidant status, and metabolites in urine after consumption of dried cranberry juice in healthy women: a pilot double-blind placebo-controlled trial. Journal of Agricultural and Food Chemistry, 55(8), 3217-3224.

Vostalova, J., Vidlar, A., Simanek, V., Galandakova, A., Kosina, P., Vacek, J., ... & Student, V. (2015). Are high proanthocyanidins key to cranberry efficacy in the prevention of recurrent urinary tract infection? Phytotherapy Research, 29(10), 1559-1567.

Xia, J. Y., Yang, C., Xu, C. F., Xiang, H. Y., Yang, L. H., & Lin, Z. X. (2021). Consumption of cranberry as adjuvant therapy for urinary tract infections in susceptible populations: A systematic review and meta-analysis with trial sequential analysis. PloS one, 16(9), e0256992.

Yung, L. M., Tian, X. Y., Wong, W. T., Leung, F. P., Yung, L. H., Chen, Z. Y., ... & Huang, Y. (2016). Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats. European Journal of Nutrition, 55(1), 55-65.


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